GALLERY: 10 Memorable Moments From Madonna’s Career

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When Madonna shocked the audience with her "Like a Virgin" performance at the first ever MTV Video Music Awards in 1984.

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That Kiss - Madonna, Britney Spears, and Christina Aguilera performed onstage during the 2003 MTV Video Music Awards, and the kisses they all shared are still topics of discussion today.

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Madonna starred In the movie "Evita" in January of 1997. She also won a Golden Globe for her performance.

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When both Playboy and Penthouse had her on their covers in July of 1985.

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When she starred in her most scandalous video to date for "Like a Prayer." This clip come out in 1989.

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When she made her acting debut in 'Desperately Seeking Susan' with Rosanna Arquette in 1985

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Everything about Madonna's 1991 'Truth or Dare' documentary was memorable.

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When she married actor Sean Penn in 1985. It only lasted four years, but It was a moment in pop culture history.

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In 1988, Madonna appeared on David Letterman's show for the first time. She also got people talking by suggesting that she was having a lesbian affair with Sandra Bernhard.

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In 1990, during her 'Blond Ambition' tour, Madonna x-rated onstage antics during 'Like A Virgin' got her show banned in Rome. The Pope also wanted fans to boycott the show. Of course, she continued to perform all over the world.